Larazotide
Larazotide Acetate (INN-202)
A synthetic octapeptide that works directly on the gut's tight junctions to reduce intestinal permeability. The most clinically studied compound for leaky gut, with multiple Phase 2 and Phase 3 trials in celiac disease patients.
Strong animal and lab research
Leaky Gut / Intestinal Permeability
Studied for blocking zonulin, a key regulator of intestinal tight junctions, to reduce pathological gut permeability. Advanced clinical trials in celiac disease patients confirm improvements in barrier function.
Celiac Disease Symptom Management
The most studied population for Larazotide. Even patients compliant with a strict gluten-free diet often have persistent gut permeability and symptoms; Larazotide is studied to address this residual dysfunction.
Gut-Immune Axis Support
By stabilizing the gut mucosal barrier, Larazotide may reduce the chronic low-level immune activation and systemic inflammation that results from intestinal permeability in autoimmune conditions.
Not medical advice. Talk to a licensed provider.