MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
A fascinating mitochondrial-derived peptide. Unlike most peptides that signal hormones, MOTS-c acts directly on your mitochondria to replicate the cellular effects of intense exercise. Known as the "exercise in a bottle" peptide.
Evidence Level · 2/5 · Restricted
Growing evidence. Some early human studies
01
Exercise Mimetic
Studied for activating AMPK (an energy-sensing enzyme), essentially tricking the body into thinking it has been exercising and rapidly boosting fat metabolism.
02
Insulin Sensitivity
Studied for powerfully shifting glucose clearance into the muscles rather than fat storage.
03
Physical Endurance
In animal models, MOTS-c supplementation drastically improved running capacity and prevented age-related physical decline.
Not medical advice. Talk to a licensed provider.